Buy andriol testocaps he preparation includes: a non-narcotic analgesic metamizol sodium, myotropic antispasmodic pitofenone and m-anticholinergic agent fenpiveriniya bromide.
Metamizole is a pyrazolone derivative. It has analgesic, antipyretic and anti-inflammatory action. Pitofenone like papaverine, has a direct effect on myotropic smooth muscles of internal organs and causes it to relax.
Fenpiveriny by m-anticholinergic action exerts additional relaxing effect on smooth muscle. The combination of the three components of the drug leads to pain relief, relaxation of smooth muscle, reduction of elevated body temperature.
Metamizole well and rapidly absorbed from the gastrointestinal tract. In the wall of the intestine is hydrolyzed to form the active metabolite -neizmenenny metamizole sodium in the blood is not available (only after the on / in the small of his concentration detected in plasma). Contact the active metabolite of protein – 50-60%. It is metabolized in the liver and excreted by the kidneys. At therapeutic doses, it penetrates into breast milk.
Following oral administration of pitofenone is its quick reabsorption from the GI tract. Maximum plasma concentration achieved within 30-60 minutes, and 0.34 – 1 mMol / l. Return with urine. The half-life is 1.8 hours.
Fenpiveriniya bromide is rapidly absorbed from the gastrointestinal tract and reaches its maximum plasma concentration within 1 hour. Report the news of 32.4 – 40.4% unchanged, buy andriol testocaps the bile is released 2.5 -5.3% of the substance.
mild to moderate pain with cramps smooth muscles of internal organs – liver and renal colic, pain, spastic nature in the course of the intestine, tuberculosis. It can be used for short-term symptomatic treatment of pain in the joints, neuralgia, sciatica, myalgia.
As an auxiliary means may be used for reducing pain after surgical and diagnostic procedures. If necessary, medication can be used to reduce elevated body temperature in cold and infectious and inflammatory diseases.
: Hypersensitivity to pyrazolone derivatives, and other components of the preparation. Inhibition of bone marrow hematopoiesis, stable and unstable angina, chronic heart failure decompensation, liver and / or kidney failure; deficiency of glucose-6-phosphate dehydrogenase; tachyarrhythmia; form-closure glaucoma; prostatic hyperplasia with a tendency to urinary retention; ileus and megacolon; bronchial asthma, urticaria, or acute rhinitis, sprovatsirovat taking acetylsalicylic acid, salicylates and other nonsteroidal anti-inflammatory drugs, granulocytopenia, pregnancy; lactation.
With caution and under medical supervision should use the drug in patients with impaired liver function or kidney problems, a tendency to arterial hypotension (systolic blood pressure below 100 mm Hg), bronchospasm. In case of violation of hematopoiesis as a result of treatment with cytostatics.
If you have one of these diseases, before taking this medication, you should consult with your doctor.
Dosing and Administration
Adults and children over 15 years is used inside (preferably after a meal) are usually ‘1-2 tablets 2-3 times a day, not liquid, squeezed small amounts of liquid. The daily dose should not exceed 6 tablets.
The duration of intake of not more than 5 days.
Increasing daily dose or duration of treatment is possible only on the advice and under the supervision of a physician.
. Dosages for children
in children the drug is used only on prescription.
Children 12-14 years: single dose – 1 tablet, the maximum daily dose – 6 tablets (1.5 tablets 4 times a day), 8-11 years – 0.5 tablet, the maximum daily dose – 4 tablets (1 tablet 4 times a day), 5-7 years – 0.5 tablet, the maximum daily dose – 2 tablets (0.5 tablets 4 times a day).
frequency. adverse reactions, listed below, was determined according to the following (World Health Organization): very often – more than 1/10; often – from more than 1/100 to less than 1/10; infrequently – from more to less than 1/100 to 1/1000; rarely – from more to less than 1/10000 1/1000; very rare – from less than 1/10000, including isolated reports.
Allergic reactions: urticaria, angioneurotic edema, in rare cases – malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome), bronchospastic syndrome, anaphylactic shock. From the mochevydelitelnoy system: renal failure, oliguria, anuria, proteinuria, interstitial nephritis, urine staining in red.
Since the cardiovascular system: blood pressure reduction.
From the side of hematopoiesis: thrombocytopenia, leukopenia, agranulocytosis (may show the following symptoms: unmotivated rise in temperature, chills, sore throat, difficulty swallowing, stomatitis, as well as the development of the phenomena of vaginitis or proctitis).
Anticholinergic effects: dry mouth, decreased sweating, paresis of accommodation, tachycardia, difficulty urinating.
In the event of certain adverse reactions, as soon as possible consult a physician.
If any of these instructions side effects are compounded, or if you notice any other side effects not mentioned in the instructions, inform your doctor.
An overdose of
the following symptoms may occur when a drug overdose: vomiting, feeling of dry mouth, sweating change, disturbance of accommodation, reduction in blood pressure, drowsiness, confusion, abnormal liver function and kidney failure, seizures.
If necessary, the simultaneous buy andriol testocaps application of these and other medications should consult a physician.
In the period of treatment is not recommended for ethanol. With long-term (more than a week) the treatment is necessary to monitor patterns of peripheral blood and functional state of the liver. If you suspect the presence of agranulocytosis or thrombocytopenia should stop taking the drug.
Must not be used for the relief of acute pain in the abdomen (to determine the cause).
Use in nursing mothers requires weaning.
Intolerance occurs rarely, but the threat of anaphylactic shock after i / v injection of the drug is relatively higher than after oral administration of the drug. In patients with atopic asthma and hay fever have an increased risk of allergic reactions.
In the treatment of patients receiving cytotoxic drugs, receive Metamizole should be done only under medical supervision. Perhaps staining of urine red due to excretion of metabolites (the clinical significance has not).
Effects on ability to drive vehicles and other complex mechanisms: during treatment should be careful when driving vehicles and occupation of potentially hazardous activities that require physical and psychomotor speed reactions.