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Lack of the second acid is a violation of DNA synthesis in the cell, preparing for chromosomal replication and division. The mechanism of action is due to the participation of folic acid in the form of a tetrahydrofolate synthesis of nucleic acids and cell division, and as a coenzyme participating in the synthesis of purines and pyrimidines, which makes it crucial factor in the formation of the central nervous system that develops in humans at 15-28 days after fertilization . The conversion of 5-methyltetrahydrofolate to tetrahydrofolate in the body can only occur by the transfer buy andriol of a methyl group to homocysteine to form methionine result of methionine. Mamifol corrects metabolism of the essential amino acid methionine, which is impaired in mothers of children with neural tube defects.

Pharmacokinetics:
Folic acid is rapidly absorbed in the jejunum while undergoing rehabilitation and methylation methyltetrahydrofolate to 5, which is present in the portal circulation.Its bioavailability after oral administration is high and ranges from 76% to 93%. Maximum plasma concentration is observed after 60 minutes. There enteric folate enterohepatic circulation, which is indispensable for the maintenance of homeostasis, such that methyltetrahydrofolate liver mainly falls into the bile, and re-enters into the colon, where it is again absorbed. Folate largely bound to plasma proteins, the liver is the main depot. Folate excreted in the urine in the form of metabolites, 10-formiltetragidrofolata and 5-methyltetrahydrofolate. Folate cross the placental barrier and is excreted in breast milk.

Indications for use:

Warning folic acid buy andriol deficiency in women of childbearing age on the stage of pregnancy planning for the prevention of neural tube defects in the fetus.

Contraindications:

Hypersensitivity to the drug component, malignancy, cobalamin deficiency. Precautions: pernicious anemia.

 

Dosage and administration:

1 tablet per day for one month before pregnancy and during the first trimester of pregnancy. The daily dose can be doubled in the case of folic acid deficiency.
The drug is taken orally before a meal.

Side effects:
Allergic reactions (erythema, itching, skin rash). At treatment doses exceeding recommended, possible violations of the gastrointestinal tract (nausea, abdominal pain, flatulence), as well as irritability and insomnia. If there are any side effects not described in this manual, you should inform your doctor.

Overdose:

folic acid doses of 4-5 mg are well tolerated. Higher doses may cause: disorders of the central nervous system and gastrointestinal tract.

 

Interaction with other drugs:

Mamifol The drug should not be taken in combination with folic acid antagonists: methotrexate and sulfasalazine, since it inhibits the enzyme gidrofolatreduktazu. Admission Mamifol drug in combination with antiepileptic drugs from the group of hydantoin (phenytoin, phenobarbital, primidone, carbamazepine or valproic acid) may reduce the effect of the latter.

 

Special instructions:

There are no data on the effect of the drug Mamifol on ability to drive and operate machinery. However, care should be taken when performing these types of operations. This product contains lactose, it should be considered for patients who have marked buy andriol difficulty with absorption of glucose or galactose, or galactosemia patients with lactase deficiency. The drug has no effective action for the prevention of neural tube defects, if the drug started after the fourth week of pregnancy. Patients with pernicious anemia, folic acid should be taken only in conjunction with cyanocobalamin.

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